Apr, 2015 insulin detemir is a prescription medication used to treat type 1 and type 2 diabetes. Insulin detemir is a longacting recombinant human insulin analog. Product monograph 100 uml, solution for injection in a. Common side effects include low blood sugar, allergic reactions, pain at the site of injection, and weight gain. Insulin detemir is a longacting basal insulin analog, with up to 24 hours duration of action, produced by a process that includes expression of recombinant dna in saccharomyces cerevisiae followed by chemical modification. Insulin detemir use is associated with higher occurrence of. Insulin detemir is a longacting insulin used to treat diabetes. Pdf effectiveness and safety of insulin glargine versus detemir. Learn about side effects, warnings, dosage, and more. Find, read and cite all the research you need on researchgate. What are the possible side effects of insulin detemir levemir, levemir flexpen, levemir flextouch. Hold the syringe with the needle pointing up in the air and. Marketed under the brand name levemir, detemir is approved for adults and children with type 1 diabetes and for adults with type 2 diabetes. To improve glycemic control in pediatric patients 2 years or older with type 1 diabetes mellitus.
Insulin detemir is an acylated insulin analog with threonine removed at. Levemir flextouch side effects, dosage, interactions drugs. Thus, provocative testing with insulin detemir produced delayed skin reaction but no immediate reaction. Produced by novo nordisk limited, levemir is the trade name for insulin detemir, a manmade form of insulin that is used as a substitute for the bodys natural insulin in diabetic patients.
Insulin detemir levemir is a longacting insulin analogue indicated for use as basal insulin therapy in patients with type 1 or 2 diabetes mellitus. Dailymed levemir insulin detemir injection, solution. Levemir is a longacting human insulin analog indicated to improve. Insulin detemir levmir for diabetes mellitus steps. You should read the instructions in this manual even if you have used an. Insulin detemir is also used to treat type 1 diabetes in adults and children who are at least 2 years old. Levemir is not meant for use to treat diabetic ketoacidosis. Levemir insulin detemir the leaflets are freely available for download and can be reproduced for free distribution to consumers. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in the insulin dose or an adjustment of concomitant antidiabetic treatment. Comparison of insulin detemir with insulin glargine in type 2. Treatment with insulin detemir once or twice daily was compared to nph insulin once, twice, or three times per day in an openlabel clinical trial of 310 pregnant women with type 1 diabetes.
Apr 17, 2020 there is limited pharmacoeconomic data on insulin detemir and no economic comparisons with nph insulin or insulin glargine. Levemir vial insulin detemir injection 100 unitsml 2 1. Levemir insulin detemir injection 100 unitsml is a manmade insulin that is used to control high blood sugar in adults and children with diabetes mellitus levemir is not meant for use to treat diabetic ketoacidosis. In limited research, it has been shown to cause slightly fewer episodes of minor hypoglycemia and no weight gain in patients. Levemir is a longacting human insulin analog indicated to improve glycemic. Diabetes mellitus type 1 dm1 is an autoimmune disease. Doses can be easily adjusted to make a customized regimen thats tailored to your bodys needs. If using a new vial, pull off the plastic protective cap, but do not remove the rubber stopper 2. Mar 24, 2020 levemir insulin detemir injection is a solution for subcutaneous use. Insulin detemir, sold under the brand name levemir among others, is a longacting insulin used to treat diabetes mellitus type 1 and type 2. Levemir is a type of longacting insulin used to treat patients with diabetes by keeping blood sugar levels under control. Apr 20, 2020 unopened vials of insulin detemir should be kept refrigerated at 28 c 3646 f and may be used until the expiration date. Insulin detemir side effects, dosage, uses, and more.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Insulin detemir is used to treat type 2 diabetes in adults. Untreated hypokalemia may cause respiratory paralysis. Insulin detemir has a molecular formula of c267h402o76n64s6 and a molecular weight of 5916. Jul 15, 2006 insulin detemir is suitable as basal insulin in a basalbolus regimen. Insulin detemir versus insulin glargine in the hospital. Read all of this leaflet carefully before you start using this medicine because it contains important. Insulin detemir has been studied in human pregnancy. Shortterm effects of nph insulin, insulin detemir, and. It is also used to treat people with type 2 diabetes condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood. Insulin detemir versus insulin glargine for type 2 diabetes. Levemir insulin detemir levemir penfill 100 uml, solution for injection in a cartridge levemir flextouch 100 uml, solution for injection in a prefilled disposable pen. Patient responses to viewing food and nonfood pictures were measured in the brain.
Insulin detemir is used to treat type 1 diabetes condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood. Insulin detemir is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours insulin detemir is used to improve blood sugar control in adults and children with diabetes mellitus insulin detemir is used to treat type 2 diabetes in adults. Insulin detemir is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Shortterm effects of nph insulin, insulin detemir, and insulin glargine on the ghigf1igfbp axis in patients with type 1 diabetes zhulin ma1,2, jens sandahl christiansen2, torben laursen3. Levemir is a manmade insulin used to control high blood sugar in adults and children with diabetes mellitus. Experimental testing of skin reactions to insulin detemir in. Levemir insulin detemir injection, for subcutaneous use fda. Levemir vial insulin detemir injection 100 unitsml. Jun 15, 2006 a new, longacting insulin analog modified, synthetic form of insulin that acts in the bloodstream for up to 24 hours. Insulin detemir is a longacting basal insulin analog, with up to 24 hours duration of action. Change from basal insulin to insulin detemir can be done on a unittounit basis then adjust to achieve glycemic targets. Insulin detemir side effects, uses, dosage, overdose. Levemir insulin detemir is a long lasting insulin that provides consistent, allday blood sugar control with less risk of low blood sugar.
Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than nph insulin in patients with type 1 diabetes on a basalbolus regimen with premeal. Thalange n, bereket a, jensen lb, hiort lc, peterkova v. Faqs levemir insulin detemir injection 100 unitsml. Levemir, inninsulin detemir european medicines agency. Levemir insulin detemir rdna origin injection injection label fda. Insulin detemir should be injected into the fatty tissue under the skin subcutaneously. Clinical trials have demonstrated lower fasting plasma glucose levels, lower variability in plasma glucose, predictable action profile and a reduced risk of nocturnal hypoglycaemia and weight gain, compared to conventional basal insulins. Listing a study does not mean it has been evaluated by the u. Insulin detemir levemir is an injectable medication used to treat type 1 and type 2 diabetes. I nsulin detemir, a longacting form of insulin, works by replacing the insulin that is normally produced by the body and by helping the body to use sugar for energy. The initial total daily insulin requirement in insulin naive patients is generally 0. Levemir insulin detemir injection 100 uml official. The fatty acid modification allows insulin detemir to reversibly bind to albumin, thereby providing slow absorption and a prolonged and consistent metabolic effect of up to 24 hours in patients with type 1 or type 2 diabetes mellitus. All insulin products, including levemir, cause a shift in potassium from the extracellular to intracellular space, possibly leading to hypokalemia.
Levemir is a clear, colorless, aqueous, neutral sterile solution. Capitals indicate lifethreatening, underlines indicate most frequent. Recent changes to the diagnostic threshold and process of universal oral glucose tolerance testing may increase the number of women diagnosed with gestational diabetes mellitus gdm by up to 50%. Insulin detemir is used to improve blood sugar control in adults and children with diabetes mellitus. Insulin is a hormone that works by lowering levels of glucose sugar in the blood. Sep 19, 2012 insulin detemir levemir is a soluble longacting human insulin analogue acylated with a 14carbon fatty acid.
Insulin detemir is a new basal insulin analogue recently available for commercial use in the uk. Jun 12, 2019 insulin detemir is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020, wolters kluwer updated. You should read the instructions in this manual even if you have.
At this time there was renewed interest in the importance of basal insulin in controlling diabetes and thus preventing or delaying complications, and so technology advanced again. Levemir is contraindicated in patients who have had hypersensitivity reactions to insulin detemir or any of the excipients. Find patient medical information for insulin detemir u100 subcutaneous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Levemir insulin detemir dosing, indications, interactions. Read the instructions for use that come with your levemir product. Dosage of human insulin, which is always expressed in usp units, must be based on results of blood and urine glucose tests and must be carefully individualized to optimal effect. Mar 23, 2005 comparison of insulin detemir with insulin glargine in type 2 diabetes the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Insulin detemir in the treatment of type 1 and type 2 diabetes. Insulin detemir is a neutral, soluble, longacting insulin analogue in which threonine is omitted from position b30 of the insulin. The first page of the pdf of this article appears above. You should read the instructions in this manual even if you have used an insulin 10 ml. Two new basal insulin analogues have come to the market. Acylation of a 14carbon chain fatty acid myristic acid to the lysine residue at position. Levemir is produced by a process that includes expression of recombinant dna in saccharomyces cerevisiae followed by chemical modification.
Levemir definition of levemir by medical dictionary. Getting started on levemir flextouch flextouchthe only prefilled insulin pen with no pushbutton extension1 accurate dosing from 1 to 80 units1 works with novo nordisk pen needlesa large, clear dosing window endofdose clickb prefilled with 300 units of levemir low injection force. Insulin detemir differs from human insulin in that the amino acid threonine in position b30 has been omitted, and a c14 fatty acid chain has been attached to the amino acid b29. Levemir flextouch side effects, dosage, interactions. Racgp allergic reactions to insulin detemir in women with. Insulin detemir is an acylated insulin analog with threonine removed at position b30, and lysine at position b29 is acylated with a 14carbon myristoyl fatty acid acylation, resulting in delayed action due to increased binding to albumin. Other drugs include recently approved symlin pramlintide acetate, as an adjunct treatment in patients who use mealtime insulin therapy and who have failed to achieve desired glucose control despite optimal insulin therapy, and levemir insulin detemir which is indicated for once or twice daily subcutaneous administration in the treatment of.
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